منابع مشابه
Cancer suppression at old age.
Increased age is regularly linked with heightened cancer risk, but recent research suggests a flattening around age 80. We report that, independent of cancer site or time period, most incidence rates decrease in the more elderly and drop to or toward zero near the ceiling of human life span. For all major organ sites, male and female, we use 1979 to 2003 Surveillance, Epidemiology, and End Resu...
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In recent years data on cancer incidence in the USA, the Netherlands, and in Hong Kong indicate a flattening and perhaps a turnover at advanced age, but no model has been successful in fitting this data and thus providing clues to the underlying biology. In this work we assume these data are reliable and free from bias. We find that a Beta distribution fits SEER age-specific cancer incidence da...
متن کاملInclusive fitness effects can select for cancer suppression into old age
Natural selection can favour health at youth or middle age (high reproductive value) over health at old age (low reproductive value). This means, all else being equal, selection for cancer suppression should dramatically drop after reproductive age. However, in species with significant parental investment, the capacity to enhance inclusive fitness may increase the reproductive value of older in...
متن کاملAge distribution of cancer in mice: the incidence turnover at old age.
We have studied cancer incidence in mice as a function of age in those cohorts where the rodents are allowed to live very close to their full natural lifetime. We find that the incidence rises as a function of age, but then flattens and turns over at an age of about 800 days. This behaviour is similar to that which we observed (Pompei and Wilson, 2001) in the Surveillance, Epidemiology, and End...
متن کاملManagement of breast cancer in old age.
In a retrospective survey of 301 women aged over 70 with breast cancer the factors affectingfive-year survival are evaluated. The local disease is more advanced when the patient presents with it in old age than in younger women, possibly associated with a lesser degree of awareness or a long history of the primary tumour. It is not associated with a different average rate of tumour growth in ol...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2008
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-07-1670